Adaptive replanning intensity-modulated radiotherapy for choroidal metastasis of breast cancer using optical coherence tomography
نویسندگان
چکیده
Swept source optical coherence tomography (SS-OCT) is a convenient method for precise, early-stage detection of choroidal metastatic lesions, involving assessment of tumor response, and for regular follow-up studies. Using information obtained with SS-OCT, we performed intensity-modulated radiotherapy (IMRT) for a patient with choroidal metastasis from breast cancer with more accuracy than had been previously possible. We made replanning adaptive radiotherapy (ART) three times based on the rapid tumor shrinkage detected by weekly assessments with SS-OCT. Accordingly, the planning target volume (PTV) decreased from 1.6 cm(3) to 0.61 cm(3) (38%), with 0.95 cm(3) (59%) and 0.75 cm(3) (46%) as intermediate values during the treatment course. The D0.1 cm3 of the right optic nerve was also reduced from 1.70 Gy/fraction to 0.69 Gy/faction, with 1.41 Gy/fraction and 1.29 Gy/fraction as intermediate values. Adaptive replanning IMRT made it possible to perform locally curative treatment of the metastatic choroidal lesion with a higher dose for the PTV, and a lower dose for organs at risk (OARs).
منابع مشابه
Indocyanine Green Mediated Photothrombosis and High Dose Intravitreal Bevacizumab as Adjuvant Therapy for Isolated Choroidal Metastasis from Breast Cancer
PURPOSE To report the effectiveness of indocyanine green mediated photothrombosis (IMP) combined with high dose (4 mg/0.16 ml) intravitreal bevacizumab (IVB) as adjunctive therapy for management of isolated choroidal metastasis from breast cancer. METHODS This retrospective interventional case report includes three eyes of two patients with choroidal metastasis from breast cancer. Both patien...
متن کاملComparison of Choroidal Thickness in Psoriasis and Control Groups Using Optical Coherence Tomography
Background and Objective: One of the most common extracutaneous complications in psoriasis patients is ocular complications, which is controversial concerning its effect on choroidal thickness. This study aimed to compare the psoriasis patients with healthy individuals in terms of the thickness of the choroidal layer using the optical coherence tomography technique. Materials and Methods: In t...
متن کاملComparison of dosimetric radiotherapy of whole left- breast cancer using conventional tangential wedge-based techniques (CTT) and three intensity modulation techniques (IMRT)
Introduction: Whole breast radiotherapy after breast-conserving surgery decrease the risk of local recurrence. this study investigates the dosimetric aspects of intensity modulated radiotherapy (IMRT) compared to conventional tangential wedge-based beams techniques (CTT) of the whole breast in early stages breast cancer patients. Materials and Methods: Co...
متن کامل[Choroidal metastasis from a breast carcinoma. Diagnosis and follow-up with optical coherence tomography and fluorescein angiography and autofluorescence with HRA-II (Heidelberg Retina Angiograph)].
CLINICAL CASE A 69-year-old woman developed choroidal metastasis from a breast carcinoma 2 years after the initial diagnosis, surgery and chemotherapy. After treatment with palliative chemotherapy and external radiotherapy, we used fluorescein angiography (FA) and optical coherence tomography (OCT) to evaluate the resolution of the serous retinal detachment, as well as a later relapse in the op...
متن کاملClinical outcomes among patients with head and neck cancer treated by intensity-modulated radiotherapy with and without adaptive replanning.
BACKGROUND The purpose of this study was to determine the effect of adaptive replanning on clinical outcome among patients treated by intensity-modulated radiotherapy (IMRT) for head and neck cancer. METHODS Three hundred seventeen patients underwent IMRT with daily image-guidance for newly diagnosed squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60-74 Gy). Of ...
متن کامل